Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is characterized by parathyroid hormone (PTH) overproduction, causing hypercalcemia. The most common cause is a parathyroid adenoma. PHPT most frequently presents as asymptomatic hypercalcemia or with nonspecific symptoms. Less frequently, it presents with the classical manifestations of bone disease and nephrolithiasis. Acute pancreatitis (AP) as the initial manifestation of PHPT has been reported rarely. Hypercalcemia can caus...

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...

IntroductionAcromegaly is an uncommon chronic disease with an insidious course. Due to the high morbimortality it causes, its early diagnosis and treatment are priority. The three therapeutic pillars are surgery, pharmacological treatment and radiotherapy, alone or in combination.ObjectivesTo clinically, biochemically and histologically characterize patients with acromegaly under follow-up in a tertiary hospi...

IntroductionAlthough surgical treatment of acromegaly is the treatment of choice in most patients, a wide therapeutic arsenal is available. Medical treatment can be indicated as primary treatment, complementary and even as pre-operative treatment.ObjectivesTo determine the prevalence of uncured acromegaly and the prevalence of controlled disease within this group. To clinically, biochemically and histological...

BackgroundAcromegaly is an infrequent chronic multisystemic disease associated with a significant morbidity and mortality rate. The treatment of choice is transsphenoidal surgery (TSS) because of its low risk of mortality and few complications.AimsTo determine the cure prevalence after TSS of growth hormone (GH) secreting pituitary adenomas. To analyze the predictive factors of non-remission after the surgery...